3. Week 13 — Home vs. Buffalo Bills
The 49ers only see the Buffalo Bills every four years, but make no mistake, these Bills are vastly different than the ones San Francisco faced back in 2016. Then again, so are the 49ers.
Buffalo is one of the most well-coached teams in the league, having reached the playoffs two out of the last three seasons. In 2019, they finished 10-6 and clinched a wild card spot.
They are favored to win the AFC East in 2020 with the New England Patriots shrouded in uncertainty and the New York Jets and Miami Dolphins facing questions of their own.
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They have an emerging young quarterback in Josh Allen and talent surrounding him on the offensive side of the ball in running back Devin Singletary and wide receivers Stefon Diggs, John Brown, and Cole Beasley.
They also have a top-ranked defense with playmakers at all three levels and coached by a defensive wizard in Sean McDermott.
It’s typically more difficult to prepare for a team that you don’t see very often, but the 49ers do have the benefit of this game being at Levi’s Stadium in primetime on a Monday Night.
However, don’t expect the Bills to shy away from the spotlight. This game is sure to be hard-fought and physical.