McCluster developed an infection in a cut on his ankle that he sustained last Sunday in the snow at Washington.
A team trainer said there were concerns McCluster had developed MRSA, the very powerful staph infection, but that test results were negative.
McCluster has 46 catches for 438 yards and a touchdown this year, but his biggest impact is on special teams. He leads the NFL with 54 punt returns, 631 punt return yards and two touchdowns on punt returns. His 11.7 yards per return is currently tied for eighth in the league.
With McCluster out, punt return duties will likely fall to Quintin Demps. The sixth-year veteran has returned 25 kickoffs this year for a 30.6 yard average and a touchdown, but has never returned a punt in a regular-season game.