According to the San Francisco Chronicle, Watson is expected to make his first NFL start, while Gurode practiced on Wednesday for the first time since injuring his quadriceps last month.
Watson played against Philadelphia as a substitute, the first NFL experience for the native of Manchester, England, who traveled a circuitous route to the National Football League. He came to the U.S. as a power forward at Marist College in New York state before he played football for the first time.
Watson played one season at Saddleback College in southern California and a year at Florida State before he was taken by the Raiders in the second round last spring.
Gurode is expected to take over for the struggling Lucas Nix up front. Gurode is a five-time Pro Bowler who was a second-round draft pick of the Dallas Cowboys back in 2002.
The big guys will be in front of quarterback Terrelle Pryor, who practiced Wednesday after spraining his knee in Sunday’s loss to the Eagles.
The running back Sunday is likely to be Rashad Jennings, who ran for 102 yards on Sunday after replacing Darren McFadden in the second quarter. McFadden has a strained hamstring.