Sept. 30, 2012; East Rutherford, NJ, USA; San Francisco 49ers quarterback Alex Smith (11) celebrates while running off the field after the game against the New York Jets at MetLife Stadium. 49ers won 34-0. Mandatory Credit: Debby Wong-US PRESSWIRE

San Francisco 49ers Look to Take Down Buffalo Bills

Coming off a 34-0 victory against the Jets last week, the San Francisco 49ers shouldn’t really have their hands full this afternoon against the 2-2 Buffalo Bills.

The 49ers’ massacre of the New York Jets was just another showing of the great San Francisco defense. And hey, their offense didn’t look too bad either.

Mark Sanchez seemed rattled the whole time, and he barely threw for over 100 yards. He didn’t even throw for a touchdown. On the other side, the Niners scored from a variety of players, as backup quarterback Colin Kaepernick even had a rushing touchdown.

Now San Francisco will be facing the Bills, who are coming off a 24-point loss to the New England Patriots. At first glance, one would say Ryan Fitzpatrick had a good game, with 350 passing yards and four touchdowns, but he also coughed the ball up with four interceptions. With Fitzpatrick having trouble against the Patriots’ defense, I can only imagine how hard it will be for Buffalo to put points up on the board against the 49ers defense, spearheaded by perennial Pro Bowl linebacker Patrick Willis.

The Bills gave up over 200 rushing yards to the Patriots last week, and hopefully Frank Gore is aware of that. Look for the 49ers’ to pound it to Gore throughout the game to test Buffalo’s defense.

San Francisco is returning home after a major win and they are hungry to tie up the NFC West at 4-1 with the Cardinals. I expect the 49ers’ defense to make Ryan Fitzpatrick uncomfortable and pass rush the heck out of him, and when that goes well, the 49ers’ are virtually unstoppable. I believe the Niners’ offense will get it done and put a lot of points up, as their offense is finally clicking together.

My prediction is that the San Francisco 49ers will take down the Buffalo Bills 28-7. To watch for yourself, tune in to CBS at 1:25 PT and catch all the action.

Tags: Candlestick Park Football NFL Patrick Willis San Francisco 49ers

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